Journal article
Immunity as a predictor of anti-malarial treatment failure: A systematic review
K O'Flaherty, J Maguire, JA Simpson, FJI Fowkes
Malaria Journal | BMC | Published : 2017
Abstract
Background: Naturally acquired immunity can reduce parasitaemia and potentially influence anti-malarial treatment outcomes; however, evidence for this in the current literature provides conflicted results. The available evidence was synthesized to determine and quantify the association between host immunity and anti-malarial treatment failure. Methods: Four databases were searched to identify studies investigating malaria antibody levels in patients receiving anti-malarial treatment for symptomatic malaria with treatment failure recorded according to the World Health Organization classification. Odds ratios or hazard ratios were extracted or calculated to quantify the association between mal..
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Grants
Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by the National Health and Medical Research Council of Australia (Project Grant (#1060785) to FJIF and JAS, an Infrastructure for Research Institutes Support Scheme Grant and a Senior Research Fellowship to JAS), the Australian Research Council (Future Fellowship to FJIF), the Australian Commonwealth Government (Australian Government Research Training Program Scholarship awarded to KO) and a Victorian State Government Operational Infrastructure Support grant. The funders had no role in the study design, data collection or analysis, decision to publish, or preparation of the manuscript.